The Next Generation Internet of Things (NGIoT) initiative is a growing community of projects and related initiatives at work to maximise the power of IoT made in Europe. NGIoT works to lower the barrier for adoption and development of IoT-empowered solutions, by supporting business models, innovation and skills. In a “network of network” ecosystem, NGIoT consists of ongoing projects and upcoming funding opportunities at work for a human-centric and sustainable digital transition. NGIoT projects are working to achieve H2020 goals while Horizon Europe will bring new opportunities to launch research and innovation projects across Europe and beyond. NGIoT works in close collaboration with related technology networks including cloud, Edge, Artificial Intelligence, 5G telecommunications networks and services, cybersecurity and blockchain. In complex IoT scenarios, people are becoming an essential part of interconnected cyber-physical systems. End users are both benefiting from connected devices and appliances as well as generating data which reinforces the effectiveness of IoT. Europe is leading the way to ensure the development and adoption of trusted and sustainable IoT that in combination with other advanced technologies can drive the digital and green transformation of our society and economy, across areas such as manufacturing, energy, agriculture, smart cities, mobility, retail and health care. The NGIoT is sharing best practices and building a growing and on-the-move ‘network of networks’ for knowledge and technology transfer, at the intersection of different research and innovation communities and industrial-driven initiatives.